El Hefny, Eman A. published the artcileSynthesis, characterization, antitumor evaluation and molecular docking of some triazolotriazine derivatives, Name: 2-Cyano-N-ethylacetamide, the publication is Journal of Pharma Research (2014), 3(5), 79-87, database is CAplus.
The synthesis of 4-amino-[1,2,4]triazolo[5,1-c][1,2,4]triazine derivatives I (R = CN, COOC2H5, CONH2) using readily available starting materials is described. In this study, six selected derivatives, compounds I (R = CN), II, III, IV (Ar = 4-ClC6H4, 2-ClC6H4) and V were subjected to a screening system for investigation of their antitumor potency against liver (HEPG2) cell line in comparison to known anticancer drugs, 5-fluorouracil and Doxorubicin. The antitumor activity results indicated that the selected compounds I (R = CN), II, III, IV (Ar = 4-ClC6H4, 2-ClC6H4) and V derivatives showed growth inhibition activity against the tested cell line but with varying intensities in comparison to 5-fluorouracil and Doxorubicin. Compounds II and III were investigated for the binding affinity of c-Kit tyrosine kinases receptor.
Journal of Pharma Research published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.
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