El-Faham, Ayman published the artcileSynthesis, characterization and anti-proliferation activity of novel cyano oximino sulfonate esters, Name: 2-Cyano-N-ethylacetamide, the publication is Chemical & Pharmaceutical Bulletin (2014), 62(4), 373-378, database is CAplus and MEDLINE.
A series of cyano oximino sulfonate derivatives RS(O)2ON:C(CN)X (R = 4-CH3C6H5, naphthalen-2-yl; X = C6H5, C2H5NH2, NH2, etc). were prepared from the reaction of arylsulfonyl chloride with different cyanoacetamide-based oximes ranging from the simplest unsubstituted amide to analogs containing N-Et (mimicking the Oxyma template), N-piperidinyl and N-morpholinyl chains. In addition, the cyano oximes, N-hydroxybenzimidoyl cyanide and N-hydroxy picolinimidoyl cyanide were also used in the synthesis of cyano oximino sulfonate derivatives The preliminary bioassays showed that some of the title compounds, such as (TsPipOx), (TsPhOX), (NpsPipOx) etc, showed anti-proliferation effect on the mouse fibroblast L929. The calculated IC50-values were ranging between 36.5 μg/mL and 0.235 mg/mL. However the anti-proliferation effects seem to be cytostatic rather than cytotoxic. The compounds only minimize the growth activity without completely killing the cells.
Chemical & Pharmaceutical Bulletin published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.
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