Duchamp, Edouard published the artcileCyanide-Free Synthesis of Air Stable N-Substituted Li and K Cyanamide Salts from Tetrazoles. Applications toward the Synthesis of Primary and Secondary Cyanamides as Precursors to Amidines, Recommanded Product: N,N-Dibenzylcyanamide, the publication is Organic Letters (2020), 22(21), 8487-8491, database is CAplus and MEDLINE.
A practical two-step synthesis of N,N’-disubstituted cyanamides such as N-allyl-N-benzylcyanamide consists in the low-temperature metalation of N-substituted 5H-tetrazoles such as 1-allyl-1H-tetrazole that undergo spontaneous cycloreversion at 0°C releasing dinitrogen, and forming N-metalated cyanamides that can be reacted in situ with a variety of electrophiles. Remarkably, N-substituted Li and K cyanamides such as lithium N-benzylcyanamide are air stable white solids at room temperature Addition of lithium organometallics to the N,N’-disubstituted cyanamides provides a new method for accessing N,N’-disubstituted amidines.
Organic Letters published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Recommanded Product: N,N-Dibenzylcyanamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics