Bhukya, Bhadru published the artcileSynthesis and anticancer activity of novel oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives, Recommanded Product: 2-Chloroacetamide, the publication is Asian Journal of Chemistry (2021), 33(6), 1331-1335, database is CAplus.
A series of novel oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives I (R = Ph, thien-2-yl; R1 = C6H5, 3-CH3C6H4, 3-FC6H4, etc.) was synthesized using 6-thiophenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine through reaction with 2-bromoethyl acetate, followed by hydrazine hydrate to afford hydrazide derivatives II (R = Ph, thien-2-yl). These compounds were further treated with aromatic acids in the presence of phosphoryl chloride and obtained oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives I. All the synthesized compounds I were screened for anticancer activity against four cancer cell lines such as HeLa – cervical cancer (CCL-2); COLO 205-colon cancer (CCL-222); HepG2-liver cancer (HB-8065); MCF7-breast cancer (HTB-22). Compounds I (R = thien-2-yl; R1 = 3-FC6H4), I (R = thien-2-yl; R1 = 3-MeOC6H4) and I (R = thien-2-yl; R1 = 3-F3CC6H4) were found to have more prominent anticancer activity at micromolar concentration
Asian Journal of Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics