Berzins, Karlis published the artcileLow-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses, Product Details of C17H14F3N3O2S, the publication is Analytical Chemistry (Washington, DC, United States) (2022), 94(23), 8241-8248, database is CAplus and MEDLINE.
In an earlier investigation, low-frequency Raman (LFR) spectroscopy was shown to detect the transition temperature of the β-relaxation (Tβ) in both amorphous celecoxib and various celecoxib amorphous solid dispersions []. In this study, we further investigated the application of this technique to determine Tβ, an important parameter for estimating crystallization potency of amorphous drugs. Alongside com. available amorphous drugs (zafirlukast and valsartan disodium salt), differently melt-quenched samples of cimetidine were also analyzed. Overall, the variable-temperature LFR measurements allowed for an easy access to the desired information, including the even lesser transition of the tertiary relaxation motions (Tγ). Thus, the obtained results not only highlighted the sensitivity, but also the practical usefulness of this technique to elucidate (subtle) changes in mol. dynamics within amorphous pharmaceutical systems.
Analytical Chemistry (Washington, DC, United States) published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Product Details of C17H14F3N3O2S.
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