Arya, V. P.’s team published research in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 16B | CAS: 14294-10-1

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Arya, V. P. published the artcilePsychoactive agents: part VIII. Isothiazoles: part VIII. Synthesis and biological activity of 4-(2-amino-4-thiazolyl)isothiazoles, Product Details of C5H10N2OS, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1978), 16B(5), 402-4, database is CAplus.

RR1NH (NRR1 = morpholino, hexahydro-1-azepinyl, octahydro-1-azocinyl, 3-azabicyclo[3.2.2]nonan-3-yl, 4-(4-fluorophenyl)piperazin-1-yl) were treated with tert-BuNCS to give RR1NCSNHCMe3, which ws debutylated to give RR1NCSNH2. This and R2CSNH2 (R2 = NH2, NHMe, NHBu, NHCH2CH:CH2, NHCH2Ph, etc.) were cyclized with I (R3 = H, Me, Et) to give the corresponding II. Among II, 4-(2-amino-4-thiazolyl)-3,5-dimethylisothiazole showed the highest analgesic activity and 4-(2-amino-4-thiazolyl)-3-methylisothiazole had the highest antiinflammatory activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics