A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications was written by Takooree, Heerasing;Aumeeruddy, Muhammad Z.;Rengasamy, Kannan R. R.;Venugopala, Katharigatta N.;Jeewon, Rajesh;Zengin, Gokhan;Mahoomodally, Mohamad F.. And the article was included in Critical Reviews in Food Science and Nutrition in 2019.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:
A review. This study endeavors to systematically review scientific data on the traditional uses, phytochem. composition, and pharmacol. properties of P. nigrum. The seeds and fruits were mostly used, and the preferred mode of preparation was in powd. form, pills or tablets and paste. Piper nigrum and its bioactive compounds were also found to possess important pharmacol. properties. Antimicrobial activity was recorded against wide range of pathogens via inhibition of biofilm, bacterial efflux pumps, bacterial swarming and swimming motilities. Improvement of antioxidant enzymes in vivo has also been reported. Piper nigrum also exhibited anticancer effect against number of cell lines from breast, colon, cervical, and prostate through different mechanisms including cytotoxicity, apoptosis, autophagy and interference with signaling pathways. Its antidiabetic property also confirmed in vivo as well as hypolipidemic activity as evidenced by decrease in level of cholesterol, triglycerides, low-d. lipoprotein and increase in high-d. lipoprotein. Piper nigrum has anti-inflammatory, anticonvulsant, neuroprotective effects. The major bioactive compound identified in P. nigrum is piperine although other compounds are also present including piperic acid, piperlonguminine, pellitorine, piperolein B, piperamide, piperettine, and (-)-kusunokinin, which also showed biol. potency. Most pharmacol. studies were conducted in vitro (n = 60) while only 21 in vivo and 1 clin. trial were performed. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics