Antibacterially active substituted anilides of carboxylic and sulfonic acids was written by Linfield, Warner M.;Micich, Thomas J.;Montville, Thomas J.;Simon, John R.;Murray, Ermellina B.;Bistline, Raymond G. Jr.. And the article was included in Journal of Medicinal Chemistry in 1983.COA of Formula: C14H19Cl2NO The following contents are mentioned in the article:
Anilides of carboxylic and sulfonic acids were prepared and tested for antimicrobial activity. Although these anilides were ineffective against gram-neg. organisms, there was a good correlation between chem. structure and biol. activity against gram-pos. species. Both the nature and position of the benzene ring substituents and the length of the C side chain affected the activity and specificity of the compounds The highest activity was observed when the acyl or sulfuryl moiety had a C7-C9 side chain attached. The -CONH- and SO2NH- bridging groups were equally effective. The attachment of COOH or COOCH3 groups in the ω-position did not affect activity, but the substitution of the acidic proton of the sulfonamide group by an alkyl group rendered the compound inactive. Six compounds, which were substituted anilides of sulfonic acids, fatty acids, or the analagous α-methylene-substituted acids, were bacteriostatic at 10 ppm against Bacillus cereus, Staphylococcus aureus, Streptococcus faecalis, and Lactobacillus plantarum. One of these compounds, the 2-hydroxy-5-nitroanilide of α-methylenedecanoic acid, was bactericidal at 1 ppm. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6COA of Formula: C14H19Cl2NO).
N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.COA of Formula: C14H19Cl2NO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics