Hussain, Khalid et al. published their research in Planta Medica in 2010 | CAS: 18836-52-7

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.HPLC of Formula: 18836-52-7

Standardization and in vivo antioxidant activity of ethanol extracts of fruit and leaf of Piper sarmentosum was written by Hussain, Khalid;Ismail, Zhari;Sadikun, Amirin;Ibrahim, Pazilah. And the article was included in Planta Medica in 2010.HPLC of Formula: 18836-52-7 The following contents are mentioned in the article:

The present study aimed to investigate standardized ethanol extracts of fruit and leaves of Piper sarmentosum for their in vivo antioxidant activity in rats using a CCl4-induced oxidative stress model. The standardization was based on the quantification of the markers pellitorine, sarmentine and sarmentosine by HPLC, and determination of total primary and secondary metabolites. The rats, divided into 7 groups each, were used as follows: group 1 (CCl4, neg. control), group 2 (untreated, control), groups 3 and 4 (fruit extract 250 and 500 mg/kg, resp.), groups 5 and 6 (leaf extract 250 and 500 mg/kg, resp.) and group 7 (vitamin-E 100 mg/kg, pos. control). The doses were administered orally for 14 days; 4 h following the last dose, a single dose of CCl4 (1.5 mg/kg) was given orally to all the groups except group 2, and after 24 h, blood and liver of each animal were obtained. Anal. of plasma and liver homogenate exhibited significant preservation of markers of antioxidant activity, total plasma antioxidant activity (TPAA), total protein (TP), superoxide dismutase (SOD), catalase (CAT), and thiobarbituric acid reactive species (TBARS), in the pretreated groups as compared to the CCl4 group. Histol. of the liver also evidenced the protection of hepatocytes against CCl4 metabolites in the pretreated groups. The results of this study indicate the in vivo antioxidant activity of both extracts of the plant, which may be valuable to combat diseases involving free radicals. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7HPLC of Formula: 18836-52-7).

(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.HPLC of Formula: 18836-52-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics