Inhibitors of the Hill reaction was written by Good, Norman E.. And the article was included in Plant Physiology in 1961.Safety of N-(3,4-Dichlorophenyl)octanamide The following contents are mentioned in the article:
Compounds (147) of the general formula RNHC(X)R’ were studied as inhibitors of the reduction of ferricyanide by illuminated chloroplasts. The following were prepared (R, X, R’, and m.p. given): octyl, O, Me2N, 27-8°; cyclohexyl, O, Me2N, 156-7°; benzyl, O, Me2N, 76-7°; and Ph, O. 2-methyl-1-propenyl, 127-9°. Similarly, 4-ClC6H4NHC(X)R'(X, R’, and m.p. given): O, Cl2CH 137-8°; O Cl3C, 127-8°; S, Et, 77-8°; O, 1-chloroethyl, 112°; O, 1,1-dichloroethyl, 94-5°; O, 2-methyl-1-propenyl, 121-2°; O, Me3C, 148-9°; and S, 4-chloroanilino, 178-9°. Similarly, 3-ClC6H4NHC(X)R’; O, H, 55-6°; O, ClCH2, 99-100°; O, Cl3C, 101-2°; O, Pr, 45-6°; O, iso-Pr, 112°; O, 2-methyl-1-propenyl, 112-13°; O, Me2N, 139-41°; and O, 4-chloro-3-butynoxy, 75-6°. Similarly, 2-ClC6H4NHC(X)R’: O, Cl3C, 62°; O, 1-chloroethyl, 59°; O, Pr, 80°; O, iso-Pr, 93-4°; O, 2-methyl-2-propenyl, 88-9°; and O, Me3C, 76. Similarly, 3,5-Cl2C6H3NHC(X)R”: O, H, 127°; O, Cl3C, 121-2°; O, Et, 118-20°; O, 2-chloroethyl, 97-8°; O, Pr, 85-6°; O, iso-Pr, 134-5°; O, 2-methyl-1-propenyl, 106-7°; and O, Me2N, 163-5°. Similarly, 3,4-Cl2C6H3NHC(X)R’: O, ClCH2, 106-7°; O, Cl3C, 124-6°; O, BrCH2, 99-101°; O, 1,1-dichloroethyl, 110-12°; S, Et, 71-2°; O, 2-chloroethyl, 112-13°; O, 2-propenyl, 120-2°; O, Me3C, 145-6°; O, sec-Bu, 112-13°; O, pentyl, 75-6°; O, heptyl, 42°; O, octyl, 69-70°; O, nonyl, 70-1°; O, Ph, 145-6°; O, 2-ClC6H4, 152-3°; O, 4-ClC6H4, 172-3°; O, 2,4-Cl2C6H3, 156-7°; O, 3,4-Cl2C6H3, 227-8°; O, cyclohexyl, 137-8°; O, benzyl, 132°; O, 3,4-dichlorobenzyl, 186-7°; O, PhOCH2 141-2°; O, 2,4-Cl2C6H3OCH2, 160-1°; O, 2-methyl-1-propenyl, 103°; O, 3-phenylpropyl, 74-5°; O, trans-2-naphthylmethyl, 157-8°; O, 1-naphthylmethyl, 170-2°; O, PrNH, 128-9°; O, BuNH, 121-2°; O, hexylamino, 104-5°; O, benzylamino, 171-2°; O, 2-hydroxylethylamino, 137-8°; O, Et2N, 111-2; O, Pr2 , 96-7°; O, iso-Pr2N, 130-1°; O, piperidino, 172-3°; S, Et2N, 95-6°; and S, EtNH, 114-15°. Similarly, iso-PrC(O)NHR: 2,3-Cl2C6H3, 108-9°; 2,5-Cl2C6H3, 137-9°; 2,4,5-Cl3C6H2 145-6°; 2,4,6-Cl3C6H2, 151-2°; 2-MeOC6H4, 44°; 4-MeOC6H4, 109-11°; 4-O2NC6H4, 167-9°; 3-O2NC6H4, 93°; 3-chloro-4-methylphenyl, 146-7°; 2-methyl-3-chlorophenyl, 142-3°; 2-methyl-4-chlorophenyl, 163-4°; 3-nitro-4-methylphenyl, 106-7°; 1-naphthyl, 147-9°; 5,6,7,8-tetrahydro-2-naphthyl, 102°; 4-Me2NC6H4, 157-8°; 2,6-dimethylphenyl, -; cyclohexyl, 116-17°; and benzyl, 91-2°. Generalizations: substitution on the 3-, 4-, or 5-positions of the benzene ring of the aniline derivatives by Cl, Br, MeO, or Me increased the inhibition. Other parts of the mol. being equal, the activity of the chloroanilides was in the decreasing order: 3,4; 3,5 and 3 and 4; unsubstituted and 2,4,5; 2,5 and 2,3; 2. p- and m-Nitro groups reduced activity slightly and p-dimethylamino reduced it greatly. The effects of modifying the acyl moiety of the anilides was too complex to classify. Polar groups reduced activity. N-Chloroacetyl-N-methylaniline, lacking an imino H, was barely inhibitory. The role of H bonding was uncertain. Substitutions on the aniline moiety which favor H bonding increased the effectiveness, but modification of the acyl moiety did not, since the imino H atoms of chloroacetyl and trichloroacetyl-3,4-dichloroaniline form bonds with carbonyl O to a very limited extent, although both were excellent inhibitors. The same was true of the triazines. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6Safety of N-(3,4-Dichlorophenyl)octanamide).
N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of N-(3,4-Dichlorophenyl)octanamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics