Correlations between acidity of substituted phenylamides and inhibition of the Hill reaction was written by Camper, N. D.;Moreland, D. E.. And the article was included in Biochimica et Biophysica Acta, Biophysics Including Photosynthesis in 1965.COA of Formula: C14H19Cl2NO The following contents are mentioned in the article:
Relative acidities of substituted phenylamides were determined by potentiometric titration with 0.1N tetrabutylammonium hydroxide methoxide in BuNH2 and expressed as half-neutralization potentials (HNP). The HNP values were correlated with inhibitory potency expressed against the Hill reaction. Of the phenylamide families studied, i.e., phenylureas, N-phenylcarbamates, and acylanilides, the phenylureas were the most acidic. Within each family, increased acidity was correlated with increased inhibition for the unchlorinated, 3- or 4-monochloro, and 3,4-dichloro derivatives, respectively. A peak occurred in the activity-acidity curve for various metasubstituted derivatives of 2-propyl N-phenylcarbamate which may be related to an optimum charge on the imino N required for high inhibitory activity. Variations in length of the side chain did not markedly affect the HNP. Substitution of an OH group for the imino H, replacement of the carbonyl O with a S atom, and chlorination and (or) unsaturation in the alkyl group increased acidity, but in general decreased inhibitory activity. A correlation between charge on the imino N and inhibition of the Hill reaction is apparent if considerations are restricted to a comparison of derivatives in which electronic rather than steric influences predominate. Steric influences are considered to control the fit, as well as the ease, with which the inhibitor approaches the active site. Electronic influences conceivably control chem. reactivity and binding of the inhibitor at the active center. This study involved multiple reactions and reactants, such as N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6COA of Formula: C14H19Cl2NO).
N-(3,4-Dichlorophenyl)octanamide (cas: 730-25-6) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.COA of Formula: C14H19Cl2NO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics