Soukup, Ondrej published the artcileThe wide-spectrum antimicrobial effect of novel N-alkyl monoquaternary ammonium salts and their mixtures; the QSAR study against bacteria, SDS of cas: 1453-82-3, the publication is European Journal of Medicinal Chemistry (2020), 112584, database is CAplus and MEDLINE.
In this study we have prepared 43 novel N-alkyl monoquaternary ammonium salts including 7 N,N-dialkyl monoquaternary ammonium salts differing bearing alkyl chain either of 12, 14 or 16 carbons. Together with 15 already published QASs we have studied the antimicrobial efficacy of all water-soluble compounds together with standard benzalkonium salts against Gram-pos. (G+) and Gram-neg. (G-) bacteria, anaerobic spore-forming Cl. difficile, yeasts, filamentous fungi and enveloped Varicella zoster virus (VZV). To address the mechanism of action, lipophilicity seems to be a key parameter which determines antimicrobial efficacy, however, exceptions are likely to occur and therefore QSAR anal. on the efficacy against G+ and G- bacteria was applied. We showed that antibacterial activity is higher when the mol. is larger, more lipophilic, less polar, and contains fewer oxygen atoms, fewer Me groups bound to heteroatoms or fewer hydrogen atoms bound to polarized carbon atoms. In addition, from an application point of view, we have formulated mixtures, on the basis of obtained efficiency of individual compounds, in order to receive wide-spectrum agent. All formulated mixtures completely eradicated tested G+ and G- strains, including the multidrug-resistant P. aeruginosa as well as in case of yeasts. Finally, 3 out of 4 formulated mixtures were safer than reference com. agent based on benzalkonium salts only in the skin irritation test using reconstructed human epidermidis.
European Journal of Medicinal Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C8H7N3, SDS of cas: 1453-82-3.
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