Abuelhassan, Suzan published the artcileSynthesis, characterization, and biological activities of some novel thienylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines and related heterocycles, Formula: C2H4ClNO, the publication is Journal of Heterocyclic Chemistry (2021), 58(9), 1784-1801, database is CAplus.
3-Cyano-5-ethoxycarbonyl-6-methyl-4-(2′-thienyl)-pyridine-2(1H)-thione was synthesized and reacted with chloroacetonitrile or chloroacetamide to give I [R1 = cyano, carbamoyl; R2 = amino], resp. Cyclocondensation of I [R1 = carbamoyl; R2 = amino] with triethylorthoformate produced the corresponding pyridothienopyrimidineone II [R3 = hydroxy], which on heating with phosphorus oxychloride gave 4-chloropyrimidine derivative II [R3 =chloro]. Compound II [R3 = chloro] was used as key intermediate for synthesizing compounds II [R3 = sulfanyl, hydrazino, piperidyl, morpholino, (3-phenyl-1H-1,2,4-triazol-5-yl)sulfanyl] upon treatment with some nucleophilic reagents such as thiourea, hydrazine hydrate, piperidine, morpholine, or 5-phenyl-s-triazole-3(1H)-thione, resp. Reaction of pyridothienopyrimidinethione II [R3 = sulfanyl] with N-(4-tolyl)-2-chloroacetamide or Et bromoacetate afforded the corresponding S-substituted methylsulfanylpyrimidines II [R3 = [2-(4-methylanilino)-2-oxo-ethyl]sulfanyl, (2-ethoxy-2-oxo-ethyl)sulfanyl]. The condensation of I [R1 = cyano; R2 = amino] with triethylorthoformate gave azomethine derivative I [R1 = cyano; R2 = ethoxymethyleneamino], which was reacted with hydrazine hydrate to give compound III [R4 = amino]. Compounds II [R3 = hydrazino] and III [R4 = amino] were used as precursors for synthesizing other new thienylpyridothienopyrimidines as well as isomeric thienyl-s-triazolopyridothieno- pyrimidines. All synthesized compounds were characterized by elemental and spectral analyses such as IR, 1H NMR, and 13C NMR. In addition, majority of synthesized compounds were tested for their antifungal activity against five strains of fungi. Moreover, compounds I [R1 = carbamoyl; R2 = amino], II [R3 = chloro, sulfanyl, (2-ethoxy-2-oxo-ethyl)sulfanyl], and III [R4 = 2-thienylmethyleneamino] were screened for their anticancer activity against HEPG-2 and MCF-7 cell lines.
Journal of Heterocyclic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Formula: C2H4ClNO.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics