Zhang, Yan published the artcileCu-Catalyzed carbamoylation versus amination of quinoline N-oxide with formamides, Category: amides-buliding-blocks, the main research area is copper catalyzed carbamoylation amination quinoline nitrogen oxide formamide; carbamoyl amino quinoline preparation cross dehydrogenative coupling radical mechanism.
An efficient, direct carbamoylation and amination of quinoline N-oxides with formamides to access 2-carbamoyl and 2-amino quinolines has been developed through copper-catalyzed C-C and C-N bond formations via cross-dehydrogenative coupling reactions. The reaction proceeds smoothly over a broad range of substrates with excellent functional group tolerance under mild conditions. Mechanistic studies suggest that the reaction is initiated by formamide radical or decarbonylative aminyl radical formation in the presence of TBHP, according to the different substituent on the N atom of formamide.
Organic & Biomolecular Chemistry published new progress about Amination. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Category: amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics