Yang, Chu published the artcileAmination of Aromatic Halides and Exploration of the Reactivity Sequence of Aromatic Halides, HPLC of Formula: 123-39-7, the main research area is amination aromatic halide DMF amine reactivity.
A base-promoted amination of aromatic halides has been developed using a limited amount of DMF (DMF) or amine as an amino source. Various aryl halides, including F, Cl, Br, and I, have been successfully aminated in good to excellent yields. Although the amination of aromatic halides with amines or DMF is usually considered as an aromatic nucleophilic substitution (SNAr) process, and the reactivity of an aromatic halide is F > Cl > Br > I, the reactivity of aromatic halides in this system was found to be I > Br ≈ F > Cl. This protocol also showed a good regioselectivity for multihalogenated aromatics This protocol is valuable for industrial application due to the simplicity of operation, the unrestricted availability of amino sources and aromatic halides, transition metal-free conditions, no requirement for solvent, and scalability.
Journal of Organic Chemistry published new progress about Amination. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics