Schaad, David R. published the artcileActivation of amide nitrogen-hydrogen bonds by iron and ruthenium phosphine complexes, Synthetic Route of 359-38-6, the main research area is amide activation iron ruthenium complex; nitrogen hydrogen bond activation amide; hydride ruthenium iron activation amide.
The complexes cis-RuHR(dmpe)2 (R = naphthyl, dmpe = Me2PCH2CH2PMe2), cis-FeH2(dmpe)2, and FeH(C6H4PPhCH2CH2PPh2)(DPPE) readily activate the N-H bonds of amides, yielding trans-MH(NHCOR1)L2 (R1 = COCF3, COC6F5, COMe, etc., L = diphosphine) products. The formation and stability of the product depend on the natures of both the metal complex and the amide employed. For the more acidic amides (e.g., trifluoroacetamide and triflamide), product formation appears to proceed via protonation of the metal complex by the amide. In the presence of excess amide, trans-RuH(NHCOR)(dmpe)2 undergoes rapid exchange of the amido ligand but not the hydride ligand.
Journal of the American Chemical Society published new progress about H-N bond. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Synthetic Route of 359-38-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics