Munoz, Maria M. published the artcileEquilibrium solubility and apparent specific volume at saturation of sodium diclofenac in {formamide (1)/N-methylformamide (1)/or N,N,-dimethylformamide (1) + water (2)} mixtures at 298.2 K, HPLC of Formula: 123-39-7, the main research area is sodium diclofenac cosolvent equilibrium solubility specific volume.
Sodium diclofenac is an analgesic drug commonly used in current therapeutics. Solubility data of this drug in aqueous cosolvent mixtures are not abundant. The main objective of this research was to determine and correlate the equilibrium solubility of sodium diclofenac in some {cosolvent (1) + water (2)} mixtures at 298.2 K. Cosolvents were formamide, N-methylformamide, and N,N-dimethylformamide. Classical shake-flask method was used to determine isothermal solubility Drug concentration measurements were performed by means of elec. conductivity determinations after adequate aqueous dilutions Solubility of sodium diclofenac increases non-linearly with the addition of cosolvent to water in almost all mixtures compositions Higher solubility values were found in {N,N-dimethylformamide (1) + water (2)} mixtures Jouyban-Acree model correlates solubility values with the mixtures composition for all cosolvent systems. Furthermore, the apparent sp. volume of this drug was also calculated from d. and mixtures compositions
Physics and Chemistry of Liquids published new progress about Cosolvents. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics