Li, Qigang published the artcileCopper-Catalyzed Enantioselective Ring-Opening of Cyclic Diaryliodoniums and O-Alkylhydroxylamines, Application of (S)-2-Methylpropane-2-sulfinamide, the main research area is cyclic diaryliodonium alkylhydroxylamine copper catalyst enantioselective ring opening atropisomer; hydroxyamino iodobiaryl stereoselective preparation.
A preparation of 2-hydroxyamino-2′-iodobiaryls via the Cu-catalyzed enantioselective ring-opening reaction of cyclic diaryliodonium salts with O-alkylhydroxylamines is reported. 3,5-Di(tert-butyl)phenyl bis(oxazoline) was found to be the optimal ligand, and up to 99% ee values were achieved. The use of CaO as the base dramatically improved the yields and inhibited the side reactions. Finally, synthetic applications of these hydroxylamines were briefly demonstrated.
Organic Letters published new progress about Atropisomers. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application of (S)-2-Methylpropane-2-sulfinamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics