Kumar, T. N. V. Ganesh published the artcileStudy of dolutegravir degradation and spectroscopic identification of products by LCMS, 1H and 13C NMR Techniques, Safety of N-Methylformamide, the main research area is dolutegravir degradation product spectroscopy NMR LC MS.
Stability study for dolutegravir bulk drug was performed and the degradation products formed were identified by chromatog. (HPLC, LCMS) and spectroscopy (ESI-MS, FTIR, 1H and 13C NMR) techniques. Degradation of the drug in acidic and peroxide environment yielded one common major degradant f ((2,4-difluorophenyl) methanamine) with a mass peak at m/z = 182.44. In addition to this, five more minor degradation products (a, b, c, d and e) were formed. The structure interpretation showed that the drug degraded to its synthetic precursor and no extra structures were formed. Hence, it was suggested that drug dolutegravir should be kept away from acidic and oxygen rich conditions.
Pharmaceutical Chemistry Journal published new progress about Decomposition. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics