Hoyt, Scott B. published the artcileDiscovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys, Computed Properties of 292170-96-8, the main research area is triazole preparation aldosterone synthase inhibitor; Aldosterone synthase; CYP11B2; hit-to-lead; hypertension.
Hit-to-lead efforts resulted in the discovery of compound I, a potent CYP11B2 inhibitor that displays high selectivity vs. related CYPs, good pharmacokinetic properties in rat and rhesus, and lead-like phys. properties. In a rhesus pharmacodynamic model, compound I displays robust, dose-dependent aldosterone lowering efficacy, with no apparent effect on cortisol levels.
ACS Medicinal Chemistry Letters published new progress about Aldosteronism. 292170-96-8 belongs to class amides-buliding-blocks, name is 5-Bromo-N,N-dimethylnicotinamide, and the molecular formula is C8H9BrN2O, Computed Properties of 292170-96-8.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics