Altomare, Cosimo published the artcileDetermination of lipophilicity and hydrogen-bond donor acidity of bioactive sulfonyl-containing compounds by reversed-phase HPLC and centrifugal partition chromatography and their application to structure-activity relations, Safety of 3-Acetylbenzenesulfonamide, the main research area is lipophilicity hydrogen acidity benzenesulfonamide aminodiphenylsulfone QSAR; structure lipophilicity hydrogen acidity benzenesulfonamide aminodiphenylsulfone.
The lipophilic character of two large series of substituted benzenesulfonamides (BzSA)and 4-aminodiphenylsulfones (4-ADS) has been assessed by two chromatog. methods, i.e. reversed-phase HPLC using a relatively novel octadecylpolyvinyl packing and centrifugal counter-current chromatog. (CPC). The octadecylpolyvinyl stationary phase proved an interesting alternative to the more common octadecylsilane type stationary phase for obtaining retention parameters correlated to partition coefficients (i.e. log P). The CPC method, being far less time-consuming and markedly more precise than the classical shake-flask method, offers a promising alternative to measuring partition coefficients The parameter Δlog Poct-hep, i.e. log Poctanol minus log Pheptane, was also examined for both congeneric series and was indicative of a similar H-bonding capacity for the SO2NH2 and 4-NH2-C6H4-SO2 groups. QSAR analyses of carbonic anhydrase inhibition by BzSA and antimycobacterial activity of 4-ADS show the capacity of the new lipophilicity parameters to express the hydrophobic component of the drug-enzyme interactions and to reveal a possible role of H-bond donor capacity in governing the antimycobacterial activity of 4-ADS.
Journal of Pharmacy and Pharmacology published new progress about Acidity. 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Safety of 3-Acetylbenzenesulfonamide.
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