Tinjaca, Dario A. published the artcileSolubility of meloxicam in aqueous binary mixtures of formamide, N-methylformamide and N,N-dimethylformamide: Determination, correlation, thermodynamics and preferential solvation, SDS of cas: 123-39-7, the main research area is meloxicam formamide n methylformamide nndimethylformamide correlation thermodn preferential solvation.
In this research the exptl. solubility of meloxicam (MLX) in {formamide (FM) + water}, {N-methylformamide (NMF) + water} and {N,N-dimethylformamide (DMF) + water} mixtures were determined at five temperatures, 293.15 K, 298.15 K, 303.15 K, 308.15 K and 313.15 K. MLX solubility increases with the cosolvent proportion in the mixtures and with temperature arising. Exptl. solubility of MLX was modelled by using three well-known cosolvency models, namely the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), Modified-Wilson model and Jouyban-Acree model. The mean relative deviation (MPD%), in the accuracy of each math. model in relation to exptl. solubility, shown CNIBS/R-K model is better in contrast to the other models. The model results were below of 3.21% for (FM + water) mixtures, to each temperature in the study. Furthermore, these were below of 1.72% for (NMF + water) mixtures and below of 1.70% for (DMF + water) mixtures, resp. Apparent thermodn. quantities of dissolution and mixing, as well as the preferential solvation parameters of MLX were calculated Gibbs energies and enthalpies of dissolution were pos. whereas the resp. entropies were neg. MLX is preferentially solvated by water mols. in water-rich mixtures but preferentially solvated by cosolvent mols. in mixtures of cosolvent-rich mixtures
Journal of Chemical Thermodynamics published new progress about Binary mixtures. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics