Prasad, Kavirayani R. published the artcileStereoselective addition of Grignard reagents to sulfinimines derived from tartrate diol (threitol): Generation of chiral building blocks for the collective total synthesis of lentiginosine, conhydrine and methyldihydropalustramate, Product Details of C4H11NOS, the main research area is stereoselective Grignard sulfinimine threitol sulfinimine; lentiginosine synthesis; conhydrine synthesis; methyl dihydropalustramate synthesis.
A systematic investigation of the addition of Grignard reagents to sulfinimines derived from tartaric acid diol was undertaken. It was observed that the chirality of the inherent tartrate moiety influences the diastereoselectivity of the resultant sulfinamides formed in the reaction. The formed products serve as excellent building blocks for the synthesis of natural products. This has been demonstrated in the collective total synthesis of lentiginosine, (+)-α-conhydrine and Me dihydropalustramate (I – III, resp.).
Tetrahedron published new progress about Chiral auxiliary. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics