Munoz, Maria M. published the artcileEquilibrium solubility and apparent specific volume at saturation of sodium sulfadiazine in some aqueous cosolvent mixtures at 298.2 K, Safety of N-Methylformamide, the main research area is sodium sulfadiazine equilibrium solubility aqueous cosolvent mixture elec conductivity.
The main objective of this research was to determine and correlate the equilibrium solubility of sodium sulfadiazine in several {cosolvent (1) + water (2)} mixtures at 298.2 K. Cosolvents were formamide, N-methylformamide, N,N-dimethylformamide, DMSO, N-methyl-2-pyrrolidone, 1,4-dioxane, and methanol. Classical shake-flask method was used to determine isothermal solubility Drug concentration measurements were performed by means of elec. conductivity determinations after adequate aqueous dilutions Solubility of sodium sulfadiazine decreases non-linearly with the addition of cosolvent to water in almost all mixtures compositions The Jouyban-Acree and Jouyban-Acree-Abraham models correlate the solubility values with the mixtures composition for all cosolvent systems. Furthermore, the apparent sp. volume of this drug at saturation was also calculated from d. and mixtures compositions
Physics and Chemistry of Liquids published new progress about Dielectric constant. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics