Li, James J. published the artcileDiscovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications, HPLC of Formula: 125328-80-5, the main research area is pyrroloimidazolidinone hydroxy preparation muscle selective androgen receptor modulator.
A novel series of imidazolin-2-ones was designed and synthesized as highly potent, orally active and muscle selective androgen receptor modulators (SARMs), with most of the compounds exhibiting low nM in vitro potency in androgen receptor (AR) binding and functional assays. Once daily oral treatment with the lead compound I (AR Ki = 0.9 nM, EC50 = 1.8 nM) for 14 days induced muscle growth with an ED50 of 0.09 mg/kg, providing approx. 50-fold selectivity over prostate growth in an orchidectomized rat model. Pharmacokinetic studies in rats demonstrated that the compound I had oral bioavailability of 65% and a plasma half-life of 5.5 h. On the basis of their preclin. profiles, the SARMs in this series are expected to provide beneficial anabolic effects on muscle with minimal androgenic effects on prostate tissue.
Journal of Medicinal Chemistry published new progress about Anabolic agents. 125328-80-5 belongs to class amides-buliding-blocks, name is N-(4-Bromo-3-chloro-2-methylphenyl)acetamide, and the molecular formula is C9H9BrClNO, HPLC of Formula: 125328-80-5.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics