Jones, Christopher R. published the artcileCan a C-H···O Interaction Be a Determinant of Conformation?, HPLC of Formula: 359-38-6, the main research area is nonconventional hydrogen bond conformation crystal structure fluoroamide.
Whether nonconventional hydrogen bonds, such as the C-H···O interaction, are a consequence or a determinant of conformation is a long-running and unresolved issue. Here we outline a solid-state and quantum mech. study designed to investigate whether a C-H···O interaction can override the significant trans-planar conformational preferences of α-fluoroamide substituents. A profound change in dihedral angle from trans-planar(OCCF) to cis-planar(OCCF) observed on introducing an acceptor group for a C-H···O hydrogen bond is consistent with this interaction functioning as a determinant of conformation in certain systems. This testifies to the potential influence of the C-H···O hydrogen bond and is consistent with the assignment of this interaction as a contributor to overall conformation in both model and natural systems.
Journal of the American Chemical Society published new progress about Bond angle, dihedral. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, HPLC of Formula: 359-38-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics