Hansch, Corwin published the artcileA quantitative structure-activity relationship and molecular graphics analysis of hydrophobic effects in the interactions of inhibitors with alcohol dehydrogenase, Formula: C2H3F2NO, the main research area is alc dehydrogenase inhibitor QSAR; liver alc dehydrogenase inhibitor QSAR; structure activity alc dehydrogenase inhibitor.
An anal. of the Ki values of pyrazoles, phenylacetamides, formylbenzylamines, and acetamides acting on liver alc. dehydrogenase (ADH) yielded quant. structure-activity relations (QSAR) having a linear dependency on octanol-water partition coefficients (P). The average coefficient and standard deviation with the log P term for 6 different QSARs was 0.96. This suggested complete desolvation of the substituents (directly comparable to partitioning into octanol) on binding to the enzyme. A study of a mol. graphics model of ADH constructed from x-ray crystallog. coordinates showed that the substituents are engulfed in a long hydrophobic channel which is so narrow that water of solvation must be removed from them in the binding process.
Journal of Medicinal Chemistry published new progress about Enzyme kinetics. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Formula: C2H3F2NO.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics