Dhawan, Sanjeev published the artcileHCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media, HPLC of Formula: 123-39-7, the main research area is secondary or tertiary amide green chemoselective preparation; aromatic hetero aryl amine formamide transamidation hydrochloric acid catalyst.
Transamidation protocol for the synthesize of secondary and tertiary amides R1R2NC(O)H [R1 = Ph, 2-HOC6H4, 3-BrC6H4, etc.; R2 = H, Me, Ph, etc.] from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst was reported. This current acid mediated strategy was beneficial because it eliminated the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification Notably, this approach conventionally used to synthesize mols. on gram scales with excellent yields and a high tolerance for functional groups.
Synthetic Communications published new progress about Amidation catalysts. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics