Thevis, Mario published the artcileMass spectrometry of hydantoin-derived selective androgen receptor modulators, Computed Properties of 125328-80-5, the main research area is hydantoin derivative preparation mass spectra androgen receptor modulator model.
N-Aryl-hydroxybicyclohydantoins represent a new class of tissue-selective anabolic agents [selective androgen receptor modulators (SARMs)] and are promising therapeutics as well as drugs prohibited in amateur and professional sport. The dissociation behavior after neg. and pos. electrospray ionization (ESI) and subsequent collision-induced dissociation (CID) was studied with drug candidate BMS 564929 (I), as well as structurally related and isotope-labeled analogs using high resolution/high accuracy orbitrap mass spectrometry. Pos. ionization and CID yielded characteristic product ions resulting from the cleavage of the hydantoin structure providing information about the proline-derived nucleus as well as the substituted aryl residue at m/z 96 and 193, resp. Neg. ESI and CID (MS/MS) yielded product ions mainly representing losses of water and CO2, the latter of which is of particular significance as the hydantoin structure does not contain a carboxyl function. Employing MSn experiments with accurate mass determination on six model SARMs, dissociation pathways to characteristic product ions were proposed supporting the identification of these drugs, their metabolites or related compounds in future doping control assays.
Journal of Mass Spectrometry published new progress about Collision-induced dissociation. 125328-80-5 belongs to class amides-buliding-blocks, name is N-(4-Bromo-3-chloro-2-methylphenyl)acetamide, and the molecular formula is C9H9BrClNO, Computed Properties of 125328-80-5.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics