Slowinski, Franck published the artcileExpeditive Access to 2-Substituted 4H-Pyrido[1,3]oxazin-4-ones via an Intramolecular O-Arylation, COA of Formula: C6H5BrN2O, the main research area is aroyl nicotinamide intramol arylation heterocyclization microwave irradiation; pyrido oxazinone preparation mol crystal structure; microwave irradiation intramol arylation heterocyclization mediator.
Unreported 2-substituted 4H-pyrido[e][1,3]oxazin-4-ones, e.g., I (X-rays single crystal structure shown), are synthesized via an unprecedented intramol. O-arylation of N-aroyl- and N-heteroaroyl-(iso)nicotinamides under microwave irradiations, in good to excellent yields. The broad applicability was demonstrated by 24 examples with a variety of substituents at the 2-position of the final compounds and 3 possible positions for the nitrogen atom of the pyridine ring. In addition, transformation of one of these compounds into 2-hydroxypyridyl-substituted 1,2,4-triazole and 1,2,4-oxazinone was realized. This approach opens a rapid access to a new bicyclic heteroaromatic chem. series with high potential in medicinal chem.
Organic Letters published new progress about Arylation (intramol., O-). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, COA of Formula: C6H5BrN2O.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics