Reitz, David B. published the artcile1H-1,2,4-triazole angiotensin II receptor antagonists: N-phenylpyridinylmethyl and N-pyridinylphenylmethyl analogs of SC-50560, Application of 3-Bromoisonicotinamide, the main research area is triazole angiotensin receptor antagonist preparation structure; phenylpyridinylmethyl triazole angiotensin receptor antagonist preparation; pyridinylphenylmethyl triazole angiotensin receptor antagonist preparation; antihypertensive triazole angiotensin receptor antagonist structure.
Substituting nitrogen for carbon in the four pyridinylphenylmethyl analogs of SC-50560 proved to be detrimental to the angiotensin II receptor-antagonist activity; however, the two phenylpyridinylmethyl analogs of SC-50560 retained their potencies. Of these two analogs, SC-52458 was found to have superior in vivo properties in the rat angiotensin II pressor assay.
Bioorganic & Medicinal Chemistry Letters published new progress about Angiotensin receptors Role: BIOL (Biological Study). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, Application of 3-Bromoisonicotinamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics