Lei, Peng published the artcileProtocol for Palladium/N-Heterocyclic Carbene-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation, Quality Control of 7465-88-5, the main research area is diaryl ketone green preparation; amide arylboronic acid Suzuki Miyaura cross coupling palladium catalyst.
A protocol for the Suzuki-Miyaura cross-coupling of amides by selective N-C(O) bond activation catalyzed by com. available, air- and moisture-stable palladium/N-heterocyclic carbene (NHC) complexes was described to obtain diaryl ketones ArC(O)Ar1 [Ar = Ph, 2-MeC6H4, 4-MeOC6H4, 4-CO2MeC6H4; Ar1 = Ph, 2-MeC6H4, 4-MeC6H4, 4-MeOC6H4, 4-CO2MeC6H4]. The procedure described involved [Pd(IPr)(cin)Cl] [IPr = 2,6-(diisopropylphenyl)imidazol-2-ylidene, cin = cinnamyl] at 0.10 mol% at room temperature and was performed on decagram scale. Furthermore, a procedure for the synthesis of amide starting materials was accomplished via selective N- tert-butoxycarbonylation, which was the preferred method over N-acylation. The present protocol carried advantages of operational simplicity, com. availability of catalysts and excellent conversions at low catalyst loadings. The method was generally useful for activation of N-C(O) amide bonds in a broad spectrum of amide precursors. The protocol should facilitate the implementation of amide cross-coupling reactions.
Synthesis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Quality Control of 7465-88-5.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics