Zhang, Xiangyu published the artcileDirect synthesis of quinazolinones via the carbon-supported acid-catalyzed cascade reaction of isatoic anhydrides with amides and aldehydes, Related Products of amides-buliding-blocks, the main research area is dihydroquinazoline preparation; quinazolinone preparation green chem phenylsilane selective hydrosilylation ruthenium catalyst; benzoxazindione amide aldehyde amidation cyclization tandem acid catalyst recycling.
A novel catalytic system is reported for the construction of quinazolinones I (R1 = H, 7-Me, 6-OMe, etc.; R2 = Me, Et, cyclopropyl; R3 = Ph, pyridin-3-yl, cyclohexyl, etc.) via the carbon-supported acid-catalyzed cascade coupling of isatoic anhydrides II with amides R2NHCHO and aldehydes R3CHO. Subsequent selective hydrosilylation of the quinazolinones I using a hydrogen-transfer strategy was also explored to provide dihydroquinazolines III with structural diversity. The developed methodol. proceeds with a broad substrate scope and excellent functional group tolerance and utilizes a reusable catalyst and air as a green oxidant.
Tetrahedron Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics