Wang, Rong-Hua published the artcileSelective C(sp3)-H Cleavage of Enamides for Synthesis of 2-Pyridones via Ligand-enabled Ni-Al Bimetallic Catalysis, Application of N-Methylformamide, the main research area is pyridone preparation regioselective; formyl enamide alkyne cyclization nickel aluminum catalyst.
Herein, a selective C(sp3)-H cleavage of N-formyl enamides R(R1)C=C(CH2(R2))N(CHO)R3 [R = H, Me; R1 = H, propan-2-yl, 4-methoxyphenyl, etc.; R2 = H; R1R2 = -((CH2)2)-, -((CH2)3)-, -(CH2CH(C6H5)CH2)-; R3 = Me, n-Pr, Ph, Bn, 3-methylbut-3-en-1-yl] without backbone modification, providing a series of 2-pyridones I [R4 = Me, Ph, thiophen-2-yl, etc.; R5 = n-Bu, Ph, thiophen-2-yl, etc.] in 58-99% yields was reported. A bifunctional phosphine oxide (PO) ligand-bridging Ni-Al bimetallic catalyst played key role in the reaction.
ACS Catalysis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics