Maegawa, Tomohiro published the artcileThe Reaction of Ketoximes with Hypervalent Iodine Reagents: Beckmann Rearrangement and Hydrolysis to Ketones, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is ketoxime hypervalent iodine Beckmann rearrangement; amide preparation; oxime hypervalent iodine reagent hydrolysis; ketone preparation.
The reaction of ketoximes with hypervalent iodine reagents was investigated. A combination of PhI(OAc) 2 and BF3·Et2O promoted the Beckmann rearrangement of ketoximes, thus yielding the corresponding amides. From a detailed investigation of the reaction, it was determined that the Beckmann rearrangement is preceded by acetylation of the hydroxy group of the ketoxime in situ, accelerating the Beckmann rearrangement. The acetylated ketoxime undergoes the Beckmann rearrangement with BF3·Et2O was confirmed. The reaction of ketoximes with Koser’s reagent [PhI(OH)OTs] in the presence of THF results in hydrolysis, affording the corresponding ketones in high yields at room temperature
Synthesis published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics