Lahosa, Alejandro published the artcileEnantiodivergent Approach to the Synthesis of Cis-2,6-Disubstituted Piperidin-4-ones, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide, the main research area is aldehyde tert butanesulfinyl imine keto acid diastereoselective decarboxylative Mannich; amino ketone stereoselective preparation; disubstituted piperidinone stereoselective preparation; alkaloid 241D preparation; epimyrtine preparation; lasubine II preparation.
Enantiopure β-amino ketone derivatives were synthesized by decarboxylative Mannich reaction of chiral N-tert-butanesulfinyl imines with β-keto acids and were subsequently transformed into cis-2,6-disubstituted piperidin-4-ones through an organocatalyzed condensation with aldehydes. Both enantiomers were accessible from the same precursors by inverting the order in the reaction sequence of the aldehydes involved in the imine formation and the intramol. Mannich condensation. The synthesis of the piperidine alkaloids (+)-241D, (-)-epimyrtine, and (-)-lasubine II demonstrated the utility of this methodol.
Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Recommanded Product: (S)-2-Methylpropane-2-sulfinamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics