Alandini, Nurtalya published the artcileAmide Synthesis by Nickel/Photoredox-Catalyzed Direct Carbamoylation of (Hetero)Aryl Bromides, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is amide preparation nickel photoredox catalyst carbamoylation heteroaryl bromide; amides; cross-coupling; nickel catalysis; photoredox catalysis; radical chemistry.
Herein, the authors report a one-electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero)aryl bromides. This radical cross-coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method’s mild reaction conditions make it tolerant of sensitive-functional-group-containing substrates and allow the installation of an amide scaffold within biol. relevant heterocycles. In addition, the authors installed amide functionalities bearing electron-poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods.
Angewandte Chemie, International Edition published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics