Yu, Xiaoqiang published the artcileSynthesis of Quinazolin-4(3H)-ones via the Reaction of 2-Halobenzamides with Nitriles, COA of Formula: C6H5BrN2O, the main research area is quinazolinone preparation; halobenzamide nitrile nucleophilic addition aromatic substitution copper acetate catalyst.
This paper described a convenient method to synthesize quinazolin-4(3H)-ones, e.g. I, from simple and readily available 2-halobenzamides and nitriles. The Lewis acid Cu-catalyzed nucleophilic addition of 2-halobenzamide to nitriles followed by SNAr reaction proceeded smoothly in the presence of t-BuOK as a base to produce the quinazolinone derivatives
Journal of Organic Chemistry published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent) (halo). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, COA of Formula: C6H5BrN2O.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics