Srinivasulu, A. published the artcileCopper-Catalyzed N-Alkyl Formamide Activation: Tandem Oxidative Coupling Approach for the Construction of C-N and C-O Bonds to Synthesize 3-Alkyl-1,3-Benzoxazine-2,4-Dione and 4-Methylene-3-Alkyl-1,3-Benzoxazine-2-One Derivatives, Application of N-Methylformamide, the main research area is alkyl benzoxazine dione preparation; salicyaldehyde alkyl formamide activation tandem oxidative coupling copper catalyst; methylene alkyl dihydrobenzoxazineone preparation; hydroxy acetophenone alkyl formamide activation tandem oxidative coupling copper.
Synthesis of 3,4-dihydro-2H-benzo[e][1,3]oxazin-2-ones I [R = Me, Et; R1= H, 6-Me, 7-OMe, etc.; X = O, CH2] via N-alkyl formamide activation by using copper/oxidant system via tandem oxidative coupling with salicyaldehydes/hydroxy acetophenones constructing C-N/C-O bond was reported. This protocol elucidated a method for the synthesis of pharmaceutically interested 3-alkyl-1,3-benzoxazine-2,4-dione and 1,3-methylene-3-alkyl-benzoxazine-2-one derivatives without the aid of toxic chems. such as phosgene or its derivatives
Advanced Synthesis & Catalysis published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent) (o-hydroxy). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics