Yuguda, Yakubu Magaji; Pandey, Rishikesh; Chavhan, Mayur Meghashyam; Mitra, Disha; Vijay, Aswathy; Ahmad, Sajjad; Daya, Minerva L.; Kumar, Shivam published an article in 2022, the title of the article was In-silico analysis for the confirmation of insulin receptor as a target for reported GLUT4 anti-diabetic natural compounds.HPLC of Formula: 456-12-2 And the article contains the following content:
There are 425 million people with diabetes in the World. There will be 629 million people with diabetes in the World in 2045. The insulin receptor controls glucose homeostasis, a physiol. mechanism that can lead to diabetes and cancer if disrupted. This study aimed to confirm the Insulin Receptor target for reported GLUT4 anti-diabetic natural compounds based on their pharmacokinetic properties, toxicity prediction, mol. docking, target anal., similar FDA approved drugs prediction, and mol. dynamic simulation. We selected 24 compounds on the basis of their mode of action from the anti-diabetic natural compounds database (ADNCD). Initially, we performed ADME anal. for the selected 24 compounds Among these 24 compounds, it has been found that 18 compounds followed the Lipinski Rule of Five. Further, we did a toxicity anal. of those 18 compounds, and it was found that 15 compounds were toxic in nature. We performed mol. docking against the Insulin Receptor (PDB ID: 1IR3) of the rest of the 3 compounds after ADME and toxicity anal. To understand the dynamic motions of the ligand-protein complex, we perform a root mean square fluctuation anal. We also checked the similarity of Apigenin from the FDA-approved drugs, but no similar mol. was found. It has been found that Apigenin was selected as the best compound as it showed the lowest binding energy and satisfied all our study parameters. Our promising findings based on preliminary and in-silico anal. need to be validated further by in-vitro and in-vivo studies. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2
The Article related to insulin receptor glut antidiabetic natural compound silico analysis, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics