Yuan, Ruiying; Dongzhi, Zhuoma; Guo, Wei; Zhen, Pu; Liu, Zhiming; Huang, Shan; Li, Bin; Yu, Jianqing published an article in , the title of the article was Hepatoprotective effect of Sophora moorcroftiana (Benth.) Benth.Ex baker seeds in vivo and in vitro.HPLC of Formula: 456-12-2 And the article contains the following content:
The leguminosae of Sophora moorcroftiana (Benth.) Benth.ex Baker is a drought-resistant endemic Sophora shrub species from the Qinghai-Tibet Plateau, and its seeds have hepatoprotective effects. To study the effect of S. moorcroftiana seeds on liver injury and the mol. mechanism underlying the beneficial effects, liquid chromatog.-mass spectrometry was used to detect the main active components in the ethanol extract of S. moorcroftiana seeds (SM). Male mice were divided into six groups (n = 8): normal control (NC), CCl4, SM (50, 100, 200 mg/kg), and di-Me di-Ph bicarboxylate (150 mg/kg) groups. Mice were treated as indicated (once/day, orally) for 14 days, and CCl4 (2 mL/kg) was administered i.p. The serum and liver of mice were used for biochem. assays. To explore the underlying mechanism, HepG2 cells were treated with SM, stimulated with tert-Bu hydroperoxide (t-BHP, 50 渭M), and analyzed by Western blotting. The major active compounds of SM were alkaloids including 22 compounds Serum alanine transaminase (ALT), aspartate transaminase (AST), and alk. phosphatase (ALP) decreased in the SM (200 mg/kg) group. SM can activate the expression of pregnane X receptor (PXR) and downstream mols. cytochrome P 4503A11 enzyme (CYP3A11), UDP glucuronosyltransferase 1 family polypeptide A 1 (UGT1A1), and inhibit the multidrug resistance protein 2 (MRP2). In addition, SM improved cell viability in t-BHP-induced HepG2 cells (64% to 83%) and decreased the activation of the mitogen-activated protein kinase (MAPK) pathway. The main compounds in SM were alkaloids. SM showed hepatoprotective effects possibly mediated by the suppression of oxidative stress through the MAPK pathway. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2
The Article related to sophora moorcroftiana baker seed hepatoprotective effect, hepg2, liver injury, mapk, pxr, oxidative stress, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2
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