Wahlang, Banrida; Gripshover, Tyler C.; Gao, Hong; Krivokhizhina, Tatiana; Keith, Rachel J.; Sithu, Israel D.; Rai, Shesh N.; Bhatnagar, Aruni; McClain, Craig J.; Srivastava, Sanjay; Cave, Mathew C. published an article in 2022, the title of the article was Associations between residential exposure to volatile organic compounds and liver injury markers.Formula: C10H11NO3 And the article contains the following content:
Occupational exposures to volatile organic compounds (VOCs) have been associated with numerous health complications including steatohepatitis and liver cancer. To address this knowledge gap, the objective of this cross-sectional study is to investigate associations between VOCs and liver injury biomarkers in community residents. Subjects were recruited from six Louisville neighborhoods, and informed consent was obtained. Exposure biomarkers included 16 creatinine-adjusted urinary metabolites corresponding to 12 parent VOCs. Serol. disease biomarkers measured included cytokertain-18 (K18 M65 and M30), liver enzymes, and direct bilirubin. The population comprised of approx. 60% females and 40% males; White persons accounted 78% of the population; with more nonsmokers (n = 413) than smokers (n = 250). In the overall population, metabolites of acrolein, acrylonitrile, acrylamide, 1,3-butadiene, crotonaldehyde, styrene, and xylene were pos. associated with alk. phosphatase. These associations persisted in smokers, with the exception of crotonaldehyde, and addition of N,N-dimethylformamide and propylene oxide metabolites. Although no pos. associations were observed for K18 M30, the benzene metabolite was pos. associated with bilirubin, irresp. of smoking status. Taken together, the results demonstrated that selected VOCs were pos. associated with liver injury biomarkers. These findings will enable better risk assessment and identification of populations vulnerable to liver disease. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3
The Article related to volatile organic compound liver injury, alp, vocs, liver injury, residential, smoking, Toxicology: Other and other aspects.Formula: C10H11NO3
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