On February 28, 2022, Varani, Tania; Abdouss, Majid; Azerang, Parisa; Tahghighi, Azar published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Acetylenic Sulfones and Acetylenic Sulfonamide Analogs: A Novel and Preferable Antimicrobial Drugs Based on Computational Strategies. And the article contained the following:
This study was done to report virtual screening and mol. docking studies of sulfacetamide derivatives as new antimicrobial drugs, belonging to the pharmacol. class of sulfonamides. For this purpose, sulfonamide functional groups from a library of chem. structures were converted into acetylenic sulfone and acetylenic sulfonamide functional groups to introduce a new class of antimicrobial drugs with mechanisms of action of dihydropteroate synthase inhibitors (DHPS). Initially, a library of compounds containing approx. 170 acetylenic sulfone ligands was created by similarity search method, and a library containing 170 acetylenic sulfonamide ligands was designed to be administered as new inhibitors. After designing, their mol. docking energies were calculated by three software programs including Arguslab4.0.1, AutoDock Vina and Molegro Virtual Docker and the results were compared in terms of binding energy. Although acetylenic sulfonamide compounds showed better results, acceptable results were observed in both groups of compounds Adsorption, distribution, metabolism and excretion (ADME) properties of acetylenic sulfones/acetylenic sulfonamide analogs were also analyzed using the admetSAR program. These new derivatives can be used in drug improvement processes for the treatment of antibacterial infections after performing further studies. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide
The Article related to cetylenic sulfonamide antimicrobial drug computational strategy, Placeholder for records without volume info and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide
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