Patel, Harsh; Vyas, Piyush; Nishant, Yadav; Nayanaben, Parmar published an article in 2022, the title of the article was Synthesis, characterization and antimicrobial activity of novel pyrimido-triazine fused heterocyclic compounds.Reference of 2-Chloroacetamide And the article contains the following content:
Condensation of aminopyrimidinethione I (R = H) with chloroacetamide afforded the corresponding acetamide I (R = H2NCOCH2) which further cyclized under basic conditions to give pyrimido[1,2-b][1,2,4]triazin-3(2H)-one II (X = H2) containing an active methylene group. The latter reacted with diazonium salts of various sulfa drugs to afford the hydrazones II [X = 4-RSO2C6H4NHN; R = H2N, (H2N)2C:N, 2-pyrimidinylamino, 2,6-dimethoxypyrimidin-4-ylamino, 5-methylisoxazol-3-ylamino, etc.]. These compounds were screened for their in vitro antibacterial activity against Gram pos. bacteria (Bacillus Subtilis, Staphylococcus aureus), Gram-neg. bacteria (Klebsiella promioe, E. coli) and antifungal activity against plant pathogens (Botryodiplodia theobromae, Nigrospora Sp., Penicillium Expansum, Rhizopus Nigricans). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide
The Article related to pyrimidotriazine furyl hydrazone sulfonamide antibacterial antifungal, Placeholder for records without volume info and other aspects.Reference of 2-Chloroacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics