King, Rodney William; Burgen, Arnold S. V. published an article in 1970, the title of the article was Sulfonamide complexes of human carbonic anhydrases ultraviolet difference spectroscopy.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:
Uv difference spectra are generated when human carbonic anhydrases B or C form complexes with aromatic sulfonamides. Difference spectra obtained using a variety of ring-substituted benzene sulfonamides show certain constant features; a broad peak, λmax 294-299 nm, a trough at 290-291 nm, a peak at 285-287 nm, and a peak at 232-234 nm. All the spectra obtained had other features, varying from sulfonamide to sulfonamide, not normally associated with protein perturbation difference spectra. A pH study using p-nitrobenzene sulfonamide has shown that these addnl. features may be accounted for by the dissociation of a proton from the amido group of the sulfonamide, causing changes in the uv absorption of the sulfonamide on formation of the complex. These results indicate that a conformational change takes place in the enzyme on binding the sulfonamide, exposing aromatic residues to the solvent, and that in the complex the sulfonamide is in the anionic state. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide
The Article related to carbonic anhydrases sulfonamides, anhydrases carbonic sulfonamides, sulfonamides carbonic anhydrases, uv spectra carbonic anhydrases, and other aspects.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics