Kavalek, Jaromir; Socha, Jaromir published an article in 1968, the title of the article was Quinoxaline series. V. Preparation of 3-hydroxy-2-methyl-6-chloroquinoxaline and 3-hydroxy-2-methyl-6-sulfamoylquinoxaline.Reference of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:
The title compounds I are potential fungicides and therapeutic agents. Thus, 17.2 g. 2-nitro-4-chloroaniline and 15.3 g. DL-MeCHBrCO2H was heated at 120° 40 hrs., the product extracted with hot aqueous NH4OH, and the extract made acid with HCl to give 4.86 g. N-(2-nitro-4-chlorophenyl)-DL-alanine, m. 162-3° (MeOH), which was hydrogenated in MeOH solution over Raney Ni, the product oxidized in 4% NaOH solution with 30% H2O2 on a steam bath and the material purified on Al2O3 to yield 11% I (R = Cl), m. 274-5°. A suspension of 7.1 g. 3-nitro-4-chlorobenzenesulfonamide, 11.2 g. NaHCO3, and 8.1 g. DL-alanine in 20 ml. MeOH and 15 ml. H2O gave on heating 48 hrs. at 90-100° 7.75 g. N-(2-nitro-4-sulfamoylphenyl)-DL-alanine, m. 233.5-6.0°, which was portionwise added to a boiling mixture of FeSO4.7H2O and 5% aqueous NH4OH. After 15 min., the mixture was filtered, the filtrate made acid, and the separated crude amide of 3-hydroxy-2-methyl-1,2-dihydro-6-quinoxalinesulfonic acid, m. 235-9°, dropwise treated with 30% aqueous H2O2 and kept 1 hr. on a steam bath to yield 69% I (R = SO2NH2), m. 325.5-7.0°. By an alternative route, I (R = SO2NH2) was obtained in 92% yield by treating amide of 4-amino-3-nitrobenzenesulfonic acid in aqueous NH4OH at 80° with a solution of FeSO4 and allowing to react the resulting 1,2-diamino-4-benzenesulfonamide, m. 173-5°, at 65° with an aqueous solution of pyruvic acid. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Reference of 3-Nitro-4-chlorobenzenesulfonamide
3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Reference of 3-Nitro-4-chlorobenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics