Kakeya, Nobuharu; Aoki, Masaru; Kamada, Akira; Yata, Noboru published an article in 1969, the title of the article was Biological activities of drugs. VI. Structure-activity relation of sulfonamide carbonic anhydrase inhibitors. 1.Application of 97-09-6 And the article contains the following content:
A study was made of the correlation of carbonic anhydrase inhibitory activity with the chem. structures of 19 derivatives of benzenesulfonamide and 3 heterocyclic sulfonamides, with reference to the physicochem. properties of the compounds A linear correlation was observed for Hammett’s σ factor against pKa, chem. shift of the sulfamoyl protons, and valence-force constant of the S:O bond. Inhibitory activity increased with a decrease of pKa, and with an increase of Hammett’s σ factor, chem. shift of the sulfamoyl protons, and the S:O valence-force constant of the sulfamoyl group. A close correlation was also found between the inhibitory activity and water solubility of the unionized mols. of benzenesulfonamides except for p-CH3NH and o-NO2 derivatives The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6
The Article related to structure activity drug, sulfonamides biol activity, carbonic anhydrase inhibitor, enzyme inhibitor structure, benzenesulfonamides enzyme, sulfonamides role: biol (biological study) and other aspects.Application of 97-09-6
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Amide – an overview | ScienceDirect Topics