Kakeya, Nobuharu; Yata, Noboru; Kamada, Akira; Aoki, Masaru published an article in 1969, the title of the article was Biological activities of drugs. VIII. Structure-activity relation of sulfonamide carbonic anhydrase inhibitors.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:
Hansch-Fujita’s method was applied to a structure-activity anal. of 22 sulfonamide derivatives with an inhibitory activity against carbonic anhydrase. Electronic parameters such as Hammett’s σ factor, ΔpKa, Dppm and Δfr , and hydrophobic parameters such as π, πc and β were employed. ΔpKa, Δppm, Δfr, π, πc and β were derived from dissociation constant, NM R chem. shift of sulfamoyl protons, S:O valence-force constant, n-oc tyl alc.-H2O partition coefficient, CHCl3-H2O partition coefficient and association constant to albumin, resp. This anal. proved to be useful in predicting not only the activity of substituted benzenesulfonamides except o-substituted derivatives but also that of 1,3,4-thiadiazole-5-sulfonamide derivatives The activity of o-substituted derivatives was satisfactorily predicted with the use of polar parameter σ* and steric constant ES. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide
The Article related to sulfonamides carbonic anhydrase, carbonic anhydrase sulfonamides, structure activity antienzymes, activity structure antienzymes, antienzymes structure activity, sulfonamides role: biol (biological study) and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide
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