Cengiz, Gokhan; Algin Yapar, Evren; Kara, Bilge Ahsen; Sindhu, Rakesh K. published an article in 2021, the title of the article was Comparison and evaluation of pharmacopoeial methods for the assessment of potency of antibiotics.COA of Formula: C8H10N2O3S And the article contains the following content:
The detection and assessment of potency of antibiotics are crucial for the pharmaceutics. The valid methods for microbiol. assays in pharmacopoeias are mainly based on statistical comparison of the data obtained by measuring the cidal activity resulting from the treatment of the antibiotic active ingredient in the composition of the pharmaceutics with the target microorganism. However, it was seen that there is no validated microbiol. method for some active ingredients. Due to microbiol. assays are indispensable methods for determining the potency of some active ingredient groups, the calculation of the potency is performed logarithmically. In either turbidimetric or chromatog. methods, the statistical evaluation of the sample is compared with the standard reference material. Anal. data obtained by chromatog. and chem. methods are linear peak areas and spectrophotometer readings. In microbiol. methods, the data obtained from the analyzes performed to determine the potency of antibiotics are the inhibition zone diameters or turbidimetric turbidity data. In this study, above-mentioned microbiol. assays are compared in the context of the main pharmacopoeias EP, USP, CP, IP and BP, and evaluated in terms of the chromatog. method and classical microbiol. method. It has been observed that chromatog. and chem. methods are not available to determine the potency of some pharmaceutical products containing antibiotics. The examinations made reveal the difficulty of analyzing some active ingredient groups according to chem. and chromatog. methods. For this reason, the importance of method validation studies is increasing in order to analyze active substances that do not have alternative anal. methods with microbiol. and chem. methods. In this study, all validated microbiol. methods were investigated, and it was aimed to determine alternative methods to chromatog. and chem. methods. It was concluded that the realization of new microbiol. methods to be validated by evaluating the methods in all differences would facilitate the study. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S
The Article related to antibiotics pharmacopoeial potency microbiol chem method, Placeholder for records without volume info and other aspects.COA of Formula: C8H10N2O3S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics