Bourdais, Jacques; Meyer, Francois published an article in 1961, the title of the article was 1,3-Benzenedisulfonamides as carbonic anhydrase inhibitors.SDS of cas: 97-09-6 And the article contains the following content:
4,5,6-XYZC6H(SO2Cl)2 (I) were prepared from the appropriate benzene derivatives and ClSO3H, and converted to the corresponding diamides (II) by boiling with concentrated aqueous NH3. The following I were prepared (X, Y, Z, % yield, and m.p. given): Me, H, H, 85, 52°; H, COCl, H, 51, 90; OH, Me, H, 47, 85-6°; Cl, Me, H, 45, 78°; Me, H, Cl, 64, 122-5°; Cl, H, Cl, 75, 122-3°; Cl, H, F, 36, 105°; Cl, Me, Cl, 41, 163-4°; Cl, Cl, Cl, 31, 178°. II prepared were (X, Y, Z, % yield, m.p., pK1 and pK2 determined in H2O + 15% MeOH at 20°, and carbonic anhydrase inhibitory activity relative to 1.0 for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide given): Me, H, H, 57, 189°, 9.3, 10.3, 0.33; CO2H (by KMnO4 oxidation of the corresponding Me compound), H, H, 22, 283°, 9.51, 10.66, 0.025; H, CONH2, H, 85, -, 8.93, 10.02, 0.33; Cl, Me, H, 36, 235°, 8.97, 10.14, 0.25; Me, H, Cl, 31, 247°, 8.98, 10.1, 0.63; Cl, H, Cl, 53, 265°, 8.52, 9.78, 1.67; Cl, H, F, 38, 229°, 8.55, 9.76, 1.0; NH2, H, Cl, 64, 254-5°, 9.34, 10.36, 0.025; Cl, Me, Cl, 39, 296-7°, 8.80, 9.98, 0.125; Cl, Cl, Cl, 30, 295°, 8.73, 9.51, 2.0; NH2, Me, Cl, 64, 282-3°, -, -, -. Also prepared were (compound, % yield, m.p., pK1, pK2, and inhibitory activity as above): 4,3,1-Cl(O2N)C6H3SO2Cl, 92, 56, -, -, -; 4,3,1-Cl(O2N)C6H3SO2NH2, 64, 176°, 9.18, -, 0.33; 1,3,4,6-Cl2C6H2(SO2NHMe)2, 51, 186°, 9.83, 10.63, 0.025. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6
3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. SDS of cas: 97-09-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics